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KMID : 0988920150130010074
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Intestinal Research
2015 Volume.13 No. 1 p.74 ~ p.79
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Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
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Song Yoon-Kyung
Park Young-Sook
Seon Choon-Sik
Lim Hye-Jin
Son Byung-Kwan
Ahn Sang-Bong
Jo Young-Kwan
Kim Seong-Hwan
Jo Yun-Ju
Lee Ji-Hyun
Kim Seung-Chan
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Abstract
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Background/Aims: Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.
Methods: Patients who underwent colonoscopic polypectomy of colorectal ad-enoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.
Results: 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with ab-normal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.
Conclusions: This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma. (Intest Res 2015;13:74-79)
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KEYWORD
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Advanced colorectal adenoma, Alcohol drinking, Risk, Liver diseases, alcoholics
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